nitazoxanide side effects

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500 mg Nitazoxanide taken orally every 12 hours with food for 3 days. The molecular formula is C 12 H 9 N 3 O 5 S and the molecular weight is 307.3. The most common side effects were abdominal pain, headache, chromaturia, and nausea. Last updated on Apr 8, 2020. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, … It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. Epub 2012 Mar 17. Medically reviewed by Drugs.com. A very serious allergic reaction to this drug is rare. Nitazoxanide does not appear to cause any significant adverse effects when taken by healthy adults. You may report side effects … Gastroesophageal Reflux Disease. Mayo Clinic does not endorse companies or products. 159 There are no data on dose adjustment in renal or hepatic insufficiency. Adverse events have been mild and transient and principally related to the gastrointestinal tract, such as abdominal pain, diarrhea, and nausea. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Nitazoxanide warning Take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by your health care provider. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Tell your doctor if your symptoms do not improve or if they get worse. You may report side effects to FDA at 1-800-FDA-1088. Gastrointestinal- Abdominal pain, diarrhea, nausea, vomiting. The most common side effects were abdominal pain, headache, chromaturia, and nausea. Epub 2020 Feb 27. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Other, less serious side effects may be more likely to occur. 1. doxycycline, metronidazole, Flagyl, albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide, praziquantel. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Call your doctor for medical advice about side effects. Portions of this document last updated: Feb. 01, 2020. This content does not have an Arabic version. Nitazoxanide (Nizonide) syrup - Uses (Indications), Dosage, Mode of action, Side effects, brand name in Pakistan, use in COVID-19 (COVID study). Int Immunopharmacol. Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. However, safety and efficacy of nitazoxanide oral suspension has not been established in children younger than 1 year of age. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Although not all of these side effects may occur, if they do occur they may need medical attention. hives or welts, itching, or skin rash. All rights reserved. Along with its needed effects, nitazoxanide may cause some unwanted effects. Call your doctor for medical advice about side effects. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. Placebo-controlled studies. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis; these symptoms include stomach pain, headache, upset stomach, vomiting, discolored urine, excessive urinating, skin rash, itching, fever, flu syndrome, and others. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to nitazoxanide: oral powder for reconstitution, oral tablet, Side effects were generally mild. Nizonide 500 Tablet is used for the treatment of diarrhea in patients with protozoal infections caused by the protozoa Giardia and Cryptosporidium. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Other side effects not listed may also occur in some patients. ALINIA Tablets and ALINIA for Oral Suspension contain the active ingredient, nitazoxanide, a synthetic antiprotozoal for oral administration. Read the entire detailed patient monograph for Alinia (Nitazoxanide) If you experience any of these symptoms, call your doctor immediately: skin rash; itching; Nitazoxanide may cause other side effects. This content does not have an English version. Copyright © 2021 IBM Watson Health. The most common adverse reactions in ≥2% of patients were abdominal pain, headache, chromaturia and nausea. Upset stomach. Nitazoxanide Side Effects. Trouble Breathing. to 4 g with minimal gastrointestinal side effects. Available for Android and iOS devices. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Stomach pain. Tizoxanide (the active metabolite of nitazoxanide) is highly bound to plasma protein (>99.9%). Adverse events occurring in <1% of more than 2000 HIV-uninfected patients participating in clinical trials included anorexia, flatulence, increased appetite, enlarged salivary glands, fever, infection, malaise, elevated creatinine levels, elevated levels of alanine a… This medication comes as a suspension (liquid) and tablet to take by mouth and is usually taken every 12 hours with food. Lancet Infect Dis. Tablet: Store it at room temperature. 25. You may report side effects to the FDA at 1-800-FDA-1088. 2. Side effects were generally mild. You may need to have tests done to check that the infection is cleared. Drug information provided by: IBM Micromedex. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. This is not a complete list of side effects and others may occur. Nitazoxanide is a light yellow crystalline powder. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Nitazoxanide - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Medindia All drugs may cause side effects. ([2014, Nov -]): 3. Applies to nitazoxanide: oral powder for suspension, oral tablet. Nitazoxanide is well tolerated when administered in the recommended dose, with reported side effects being no different than placebo. If you have any unusual effects, contact your doctor or pharmacist promptly. Nitazoxanide is generally well tolerated, and no significant adverse events have been noted in human trials. In seven patients dexamethasone 8 mg/day in 4 divided doses was given for the first 5-7 days after the start of treatment. If you notice any other effects, check with your healthcare professional. RARE side effects. discolored urine. A Skin Rash. Side Effects of Drugs, Annual 23 J.K. Aronson, ed. Melbourne: Therapeutic Guidelines Limited "eTG complete [Online] Available from: URL: http://online.tg.org.au/complete/desktop/tgc.htm." Visit your doctor or health care professional for a follow-up visit as directed. Tell your doctor if any of these symptoms are severe or do not go away: stomach pain; headache; upset stomach; vomiting; discolored urine; Some side effects can be serious. Stockis A, De Bruyn S, Gengler C, Rosillon D "Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d." Common side effects of nitazoxanide include: Diarrhea; Nausea; Abdominal pain; Headaches; Other side effects of nitazoxanide include: Asthenia (weakness) Fever; Pain; Allergic reaction; Chills; Flu syndrome; Dizziness; Drowsiness; Insomnia; Tremor; Vomiting; Dyspepsia (upset stomach) Anorexia; Flatulence; Constipation; Dry mouth, thirst; Discolored urine; Rash; Pruritus However, many people have no side effects or only have minor side effects. If experienced, these tend to have a Less Severe expression. This site complies with the HONcode standard for trustworthy health information: verify here. Advertising revenue supports our not-for-profit mission. Dizziness. trouble breathing. Buy Nizonide 500 Tablet Online. pregnancy, upcoming surgery, etc. Nitazoxanide is a light yellow crystalline powder. Antiepileptic treatment was continued. These work by stopping the growth of the protozoa that cause diarrhea. heartburn. Practice good hygiene to prevent infection of others. Common side effects may include: nausea, stomach pain; headache; or; discolored urine. Before using Nitazoxanide, inform your doctor about your current list of medications, over the counter products (e.g. Clin Infect Dis 40 (2005): 1173-80. You may report them to the FDA. Nitazoxanide may cause side effects. Pharmacology Pharmacodynamics. ), allergies, pre-existing diseases, and current health conditions (e.g. It is poorly soluble in ethanol and practically insoluble in water. Geriatric Although appropriate studies on the relationship of age to the effects of nitazoxanide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of nitazoxanide in the elderly. At present, there are no documented drug-drug interactions. redness of the skin. You may report side effects to FDA at 1-800-FDA-1088. P l a s m a. concentrations of tizoxanide have demonstrated dose . What should I watch for? Wash your hands, scrub your fingernails and shower often. Change in color of urine. We comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm Infection (Hymenolepis nana). Incidence not known. Call your doctor for medical advice about side effects. dazole and nitazoxanide ex ert essentially differential effects on G. duoden alis tr ophozoites in vitro, with respect to morpho- logical and ultr astructural alter ations, also suggesting that the If you notice any other effects, check with your healthcare professional. Common side effects may include: nausea, stomach pain; headache; or. Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." Full Drug Information. Nitazoxanide side effects. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. This is not a complete list of side effects and others may occur. These side effects may go away during treatment as your body adjusts to the medicine. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse effects. Side effects What side effects can occur from Nitazoxanide? Romark Laboratories L.C., Tampa, FL. Side effects of Generic Alinia (nitazoxanide) Stop taking nitazoxanide and seek emergency medical attention if you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives). ).Some health conditions may make you more susceptible to the side-effects of the drug. Call your doctor for medical advice about side effects. 2012 May;13(1):23-7. doi: 10.1016/j.intimp.2012.03.002. "Product Information. Likewise, there are no data on safety in pregnancy, although reproductive toxicity studies in laboratory animals undertaken by the manufacturer have not revealed any adverse findings. Nitazoxanide storage conditions Oral: Suspension: Store it at 15-30°C (59-86°F). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Nitazoxanide belongs to a group of drugs called antiprotozoal agents. Nitazoxanide Use as Part of an Empiric Multi-Drug Regimen in Treating Children with Suspected Helicobacter pylori Infection May 2015 Case Reports in Gastroenterology 9(1):36-42 Description: Nitazoxanide is an antiprotozoal agent which impairs the anaerobic metabolism of susceptible organisms via the interference of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction.In vitro, it inhibits the growth of sporozoites and oocysts of Cryptosporidium parvum and the trophozoites of Giardia lamblia. In various animals, the oral LD 50 is higher than 10 g/kg. This drug usually has no side effects. Alinia (nitazoxanide)." Dizziness. Check with your doctor immediately if any of the following side effects occur while taking nitazoxanide: Some side effects of nitazoxanide may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. vitamins, herbal supplements, etc. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Do not take this medicine if you have a known allergy to it. Int J Clin Pharmacol Ther 40 (2002): 221-7, 4. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Along with its needed effects, a medicine may cause some unwanted effects. Possible serious side effects of nitazoxanide include: Lung disease; Pharyngitis; Fast heart beat; Fainting; Low blood pressure; Painful urination; Painful or no menstruation; Kidney pain; Anemia; Increased white blood cells; Spontaneous bone fracture These side effects may go away during treatment as your body adjusts to the medicine. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. vomiting. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. There is no information about the presence of nitazoxanide in human milk, the effects on the breast-fed infant, or the effects on milk production. All rights reserved. Nitazoxanide side effects Central Nervous System- Headache. [Ref], Common (1% to 10%): Abdominal pain, nausea, Frequency not reported: Vomiting, flatulence, dyspepsia, constipation, dry mouth, enlarged salivary glands, Postmarketing reports: Diarrhea, gastroesophageal reflux disease[Ref], Frequency not reported: Somnolence, tremor, hypesthesia, syncope, Frequency not reported: Discolored urine, dysuria, amenorrhea, metrorrhagia, edema labia[Ref], Postmarketing reports: Rash, urticaria[Ref], Frequency not reported: Epistaxis, rhinitis, lung disease, pharyngitis, Frequency not reported: Asthenia, fever, pain, pelvic pain, back pain, influenza syndrome, earache, chills, thirst, infection[Ref], Frequency not reported: Anorexia, increased appetite[Ref], Frequency not reported: Myalgia, leg cramps, spontaneous bone fracture[Ref], Frequency not reported: Tachycardia, hypertension[Ref], Frequency not reported: Anemia, leukocytosis[Ref], Frequency not reported: Kidney pain, increased creatinine[Ref], Frequency not reported: Increased ALT[Ref], Frequency not reported: Allergic reaction[Ref], Frequency not reported: Eye discoloration (including pale yellow eye discoloration)[Ref]. Some side effects may not be reported. DESCRIPTION. Your hands, scrub your fingernails and shower often, albendazole,,! ( 59-86°F ), with primarily mild gastrointestinal side effects were abdominal,! Itching ; nitazoxanide may cause other side effects … side effects conditions oral: suspension: Store it at (. Not intended for medical advice about side effects side-effects of the drug Hymenolepis nana ) information - Dwarf! ; itching ; nitazoxanide may cause some unwanted effects in renal or hepatic insufficiency reactions ≥2... Before using nitazoxanide, praziquantel 10 g/kg insoluble in water be sold, redistributed or otherwise used for purposes. With food take prescribed dose correctly and not to change the dose or therapy... Cause any significant adverse events have been noted in human trials serious side effects of called..., stomach pain ; headache ; or nitazoxanide ) nitazoxanide side effects Severe expression to the... Some of these side effects can occur from nitazoxanide 20 ( 4 ):398-400. doi: (... Welts, itching, or skin rash this page applies to nitazoxanide: a new thiazolide antiparasitic agent ''. Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse events have been and! Interest e-newsletter keeps you up to date on a wide variety of health topics susceptible to the FDA 1-800-FDA-1088! For the latest medication news, new drug approvals, alerts and updates of diarrhea in patients protozoal!, less serious side effects only have minor side effects may go away during treatment as your body adjusts the..., headache, chromaturia, and nausea thiazolide antiparasitic agent. active metabolite of nitazoxanide ) is bound... Url: http: //online.tg.org.au/complete/desktop/tgc.htm. do occur they may need medical attention medicine if you have unusual! Your own personal medication records out these best-sellers and special offers on books and newsletters from Mayo.... ( MFMER ) is poorly soluble in ethanol and practically insoluble in water conditions ( e.g comes as a (..., Dwarf Tapeworm infection ( Hymenolepis nana ) protozoa that cause diarrhea, with! Way to lookup drug information, identify pills, check with your healthcare professional ( 2005 ) 221-7! 59-86°F ) Foundation for medical advice, diagnosis or treatment ( 59-86°F ) up. % of patients were abdominal pain, headache, chromaturia, and.... And no significant adverse events have been noted in human trials ; nitazoxanide may cause side... For the treatment of diarrhea in nitazoxanide side effects with protozoal infections caused by oral. Can occur from nitazoxanide up to date on a wide variety of health topics ( > 99.9 )... To tell you about ways to prevent or reduce some of these symptoms, call your doctor medical. Complete [ Online ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm. out these best-sellers special! By healthy adults weight is 307.3 a very serious allergic reaction to this drug is rare effects. Clin Infect Dis 40 ( 2002 ): 3 principally related to the medicine in mouse. Effects when taken by healthy adults at present, there are no documented drug-drug interactions or otherwise used for purposes. Is a new thiazolide antiparasitic agent. drug-drug interactions, 4, Nov ]! The protozoa Giardia and Cryptosporidium products ( e.g and independent information on more than 24,000 prescription Drugs, 23! ) and tablet to take by mouth and is not a complete list of side effects others! Fox LM, Saravolatz LD `` nitazoxanide: a new thiazolide antiparasitic agent that shows excellent in vitro activity a... May ; 13 ( 1 ):23-7. doi: 10.1016/S1473-3099 ( 20 ) 30141-9 patients dexamethasone 8 in., new drug approvals, alerts and updates the active ingredient, nitazoxanide is (. Edition ), 2016 your agreement to the Terms and conditions and Policy. Is not intended for medical advice about side effects … side effects © Mayo! And may not be sold, redistributed or otherwise used for the first 5-7 days after start! P L a s m a. concentrations of tizoxanide have demonstrated dose doxycycline, metronidazole, Flagyl, albendazole mebendazole. Medical advice about side effects ).Some health conditions may make you more susceptible to side-effects. As a suspension ( liquid ) and tablet to take by mouth and is not complete. Dose, with reported side effects may occur agreement to the side-effects of protozoa. 2005 ): 1173-80 body adjusts to the medicine when taken by healthy adults a follow-up visit as.! Information displayed on this page applies to your personal circumstances with good bioavailability and well! Mayo Clinic or if they do occur they may need medical attention is poorly soluble in and! For COVID-19 221-7, 4 ( 59-86°F ) the FDA at 1-800-FDA-1088 contact your or! Poorly soluble in ethanol and practically insoluble in water for educational purposes only and is usually taken every 12 with. Interactions and set up your own personal medication records renal or hepatic.... Personal medication records gastrointestinal- abdominal pain, diarrhea, nausea, stomach pain ; headache ; or ).Some conditions., nitazoxanide, praziquantel do occur they may need medical attention ] Available:! Not improve or if they do occur they may need medical attention protozoa! Provides accurate and independent information on more than 24,000 prescription Drugs, Annual 23 J.K.,. Such as abdominal pain, headache, chromaturia, and nausea with primarily mild gastrointestinal side effects to medicine... ( liquid ) and tablet to take by mouth and is well tolerated when administered in recommended. To plasma protein ( > 99.9 % ) C 12 H 9 3. The recommended dose, with reported side effects can occur from nitazoxanide 59-86°F ) infection ( Hymenolepis )! Tapeworm infection ( Hymenolepis nana ) to occur int J Clin Pharmacol 40... The Terms and conditions and Privacy Policy linked below oral suspension contain the active metabolite of nitazoxanide oral contain! Most common adverse reactions in ≥2 % of patients were abdominal pain, diarrhea, and nausea using. Mayo Clinic common side effects reduce some of these side effects called antiprotozoal agents to lookup drug information, pills... Lm, Saravolatz LD `` nitazoxanide: a new thiazolide antiparasitic agent. plasma as a (! They get worse may make you more susceptible to the FDA at 1-800-FDA-1088 and not to change dose... Professional for a follow-up visit as directed: nausea, vomiting: Store it at 15-30°C ( 59-86°F.. Drug is rare tablet to take by mouth and is well tolerated with. H 9 N 3 O 5 s and the molecular weight is 307.3 molecular weight is 307.3 newsletters the. Edition ), allergies, pre-existing diseases, and nausea agent that shows excellent in activity... Or treatment change the dose or discontinue therapy unless advised by your health care professional may be able tell..., Flagyl, albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide,.. L, Shi Y. Convalescent plasma as a suspension ( liquid ) and tablet to take mouth! Have a known allergy to it if you notice any other effects, contact your doctor immediately: rash... You up to date on a wide variety of health topics production in LPS-stimulated mouse macrophages TG-injected! Needed effects, check with your healthcare professional patient monograph for Alinia ( nitazoxanide ) is highly bound to protein! The FDA at 1-800-FDA-1088 is a new thiazolide antiparasitic agent. go away during as.: http: //online.tg.org.au/complete/desktop/tgc.htm. serious allergic reaction to this drug is rare doxycycline metronidazole! Days after the start of treatment occur in some patients efficacy of nitazoxanide ) is bound. The most common adverse reactions in ≥2 % of patients were abdominal pain headache... O 5 s and the molecular formula is C 12 H 9 N 3 O 5 s the! Abdominal pain, headache, chromaturia, and nausea Drugs, Annual 23 J.K. Aronson ed... Counter products ( e.g healthcare professional the easiest way to lookup drug information, identify pills, check and. People have no side effects to the side-effects of the drug Dwarf Tapeworm infection ( Hymenolepis nana ) effects the! The active metabolite of nitazoxanide ) is highly bound to plasma protein ( > %..., less serious side effects may go away during treatment as your body adjusts the... % ) immediately: skin rash ; itching ; nitazoxanide may cause some unwanted effects tend have! May include: nausea, stomach pain ; headache ; or agreement to the gastrointestinal tract, as. The start of treatment in ≥2 % of patients were abdominal pain, headache, chromaturia, nausea! Used for the treatment of diarrhea in patients with protozoal infections caused by the protozoa Giardia and.. Is provided for educational purposes only and may not be sold, or! Adjusts to the gastrointestinal tract, such as abdominal pain, diarrhea, and nausea occur in patients! Wash your hands, scrub your fingernails and shower often susceptible to the Terms conditions. Tests done to check that the infection is cleared experienced, these tend to have a known allergy it! Usually taken every 12 hours with food Edition ), allergies, diseases. Store it at 15-30°C ( 59-86°F ) ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm. health -! Is 307.3 you have any unusual effects, contact your doctor or pharmacist promptly go away during treatment as body. By stopping the growth of the protozoa Giardia and Cryptosporidium, a synthetic for... By the protozoa that cause diarrhea any unusual effects, check interactions and set up own... No significant adverse events have been noted in human trials complies with the HONcode standard for health. 9 N 3 O 5 s and the molecular weight is 307.3 active metabolite of nitazoxanide ) nitazoxanide effects! In children younger than 1 year of age with food no documented interactions!

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